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Degradation Analysis of 3D Printed PLA in Simulated Body

scaffold performance and the extension of this research
framework to other bioresorbable polymers such as PCL. In
particular, investigating how scaffold geometry affects not only
degradation kinetics, but also cellular behaviours, such as
endothelial cell attachment, proliferation and viability, will be
crucial for developing next-generation bioresorbable scaffolds
tailored for vascular and orthopaedic tissue engineering
applications. In summary, geometry-informed design holds
significant potential for optimising PLA-based scaffolds for bone
tissue engineering applications.

ACKNOWLEDGEMENTS

This work was funded by the Fundamental Research Grant
Scheme (FRGS) under a grant number of
FRGS/1/2021/TK0/UNIMAP/02/19 from Ministry of Higher
Education Malaysia. The authors acknowledge the financial
support from Erasmus+ CBHE project GetInnovative4Impact,
funded by the European Union (Project Number: 101083121).
Views and opinions expressed are however those of the author(s)
only and do not necessarily reflect those of the European Union.
Neither the European Union nor the granting authority can be held
responsible for them.

REFERENCES

Brito, J., Andrianov, A. K., & Sukhishvili, S. A. (2022). Factors
controlling degradation of biologically relevant synthetic
polymers in solution and solid state. ACS Applied Bio
Materials, 5(9), 5057–5076.
Chen, F., Ekinci, A., Li, L., Cheng, M., Johnson, A. A., Gleadall,
A., & Han, X. (2021). How do the printing parameters of
fused filament fabrication and structural voids influence the
degradation of biodegradable devices? Acta Biomaterialia,
136, 254–265.

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